3-(1,2-dimethyl-1H-imidazol-5-yl)nitrobenzene → 3-(1,2-dimethyl-1H-imidazol-5-yl)aniline
반응식
[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[C:9]([N+:13]([O-])=O)[CH:10]=[CH:11][CH:12]=2)=[CH:5][N:4]=[C:3]1[CH3:16]>CO.[Pd]>[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[NH2:13])=[CH:5][N:4]=[C:3]1[CH3:16]참가 물질
4
실험 절차
A suspension of 3-(1,2-dimethyl-1H-imidazol-5-yl)nitrobenzene (19.2 g) in methanol (200 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 5 g) under hydrogen atmosphere for 10 hours. After the catalyst was filtered off, the filtrate was evaporated under reduced pressure. The residue was triturated with ethyl acetate and diisopropyl ether to give 3-(1,2-dimethyl-imidazol-5-yl)aniline (14.65 g).
후처리
- filtrationAfter the catalyst was filtered off
- customthe filtrate was evaporated under reduced pressure
- customThe residue was triturated with ethyl acetate and diisopropyl ether
출처 및 근거
- ORD 기록
- ord-0eb2a3f57efd4257993c6c8aba6074ae
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06770667B1
반응 노트
불러오는 중…