2,5-Dimethyl-p-phenylenediamine → (4-Amino-2,5-dimethyl-phenylamino)-2,6-di-tert-butyl-phenol

HRID 1835629

반응식

HRID 1835629 반응식
BrC[C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]([OH:13])=[C:5]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:4]=1.[CH3:18][C:19]1[CH:24]=[C:23]([NH2:25])[C:22]([CH3:26])=[CH:21][C:20]=1[NH2:27]>O1CCCC1>[NH2:25][C:23]1[C:22]([CH3:26])=[CH:21][C:20]([NH:27][C:8]2[C:7]([C:9]([CH3:10])([CH3:11])[CH3:12])=[C:6]([OH:13])[C:5]([C:14]([CH3:15])([CH3:16])[CH3:17])=[CH:4][CH:3]=2)=[C:19]([CH3:18])[CH:24]=1

참가 물질

4

반응물 2

HCID 1608242,5-Dimethyl-p-phenylenediamine2회HCID 612973Phenol, 4-(bromomethyl)-2,6-bis(1,1-dimethylethyl)-2회

생성물 1

HCID 86759498(4-Amino-2,5-dimethyl-phenylamino)-2,6-di-tert-butyl-phenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

4-Bromomethyl-2,6-di-tert-butyl-phenol (2.42 g, 0.008 mole) was dissolved in 50 mL of dry tetrahydrofuran. In a separate conical flask 2,5-dimethyl-benzene-1,4-diamine (2.17 g, 0.016 mole) was dissolved in 25 mL of tetrahydrofuran and solution was transferred to a cylindrical funnel with pressure equalizing tube. Three-necked round-bottom flask containing solution of 4-Bromomethyl-2,6-di-tert-butyl-phenol was kept in oil-bath at 85° C. Solution in the flask was continuously stirred with the help of magnetic stirrer. 2,5-dimethyl-para-phenylene diamine solution was added drop-by-drop, from funnel to the flask in acidic medium for a span of 4-5 hours till all the solution was poured out. The reaction was terminated after that and the final reaction mixture was allowed to attain room temperature. Product was separated by solvent evaporation. The product was purified using silica gel column chromatography. Product was identified by 1H-NMR. The yield of 4-[(4-Amino-2,5-dimethyl-phenylamino)-2,6di-tert-butyl-phenol is 1.86 g (65%).

후처리

  1. customsolution was transferred to a cylindrical funnel with pressure
  2. customwas kept in oil-bath at 85° C
  3. additionwas poured out
  4. customThe reaction was terminated after that and the final
  5. customreaction mixture
  6. customto attain room temperature
  7. customProduct was separated by solvent evaporation
  8. customThe product was purified

출처 및 근거

ORD 기록
ord-86f04b26e8e04787a808175bb016cfe7
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06770785B1

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