Water → HCID 2794448, 화합물

HRID 1835687노트

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HRID 1835687 반응식
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

참가 물질

6

반응물 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

생성물 1

HCID 2794448HCID 2794448, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

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온도
125 °C

실험 절차

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

후처리

  1. additionwas added The mixture
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

출처 및 근거

ORD 기록
ord-474de6f4f16d4f82961aa3bac26dbc04
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06774103B1

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