Methylamine → 6-AMINO-1-BENZYL-5-METHYLAMINOURACIL

HRID 1835737노트

반응식

HRID 1835737 반응식
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1Br.[CH3:18][NH2:19]>>[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6](=[O:15])[NH:5][C:4](=[O:16])[C:3]=1[NH:19][CH3:18]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 8221496-Amino-1-benzyl-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione

생성물 1

HCID 7262256-AMINO-1-BENZYL-5-METHYLAMINOURACIL

반응 조건

온도
5 °C

실험 절차

6-Amino-1-benzyl-5-bromouracil (134 g) was stirred with 40% aqueous methylamine solution (750 ml) for 24 hours. After cooling to 5° C., the precipitate was filtered and dried under suction to provide 6-amino-1-benzyl-5-methylaminouracil (55 g).

후처리

  1. filtrationthe precipitate was filtered
  2. customdried under suction

출처 및 근거

ORD 기록
ord-6bc904fd93b245ef8f570b41f7532b0a
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06774130B2

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