Formaldehyde → Hydroxyethyl methyltolylamine

HRID 1835901노트

반응식

HRID 1835901 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1.[H][H].[CH2:14]=O>[Pd].O>[CH3:14][N:4]([CH2:3][CH2:2][OH:1])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 2200082-p-Tolylamino-ethanolHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 76094Hydroxyethyl methyltolylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

N-(2-hydroxyethyl)-p-toluidine, 50 g, was combined with 1 g 5% palladium on carbon catalyst and charged to a pressure reactor. The pressure reactor was heated to 120° C. and fed hydrogen gas to maintain 120 psig pressure. Formaldehyde, 178 g 37% solution in water, was fed to the pressure reactor over 10 hours. After hydrogen uptake ceased, the reaction mass was filtered to remove catalyst and decanted to separate the aqueous phase.

후처리

  1. additioncharged to a pressure reactor
  2. temperatureto maintain 120 psig pressure
  3. filtrationthe reaction mass was filtered
  4. customto remove catalyst
  5. customdecanted
  6. customto separate the aqueous phase

출처 및 근거

ORD 기록
ord-63cdedb8f8264a4daffc54fbe30d9c76
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06774193B2

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