Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Chloro-4-methoxybenzylamine | HCID 738038 | — |
| 반응물 | methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d)pyrimidin-5-yl]propionate | HCID 11150640 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate | HCID 11774810 | 105.3% |
반응 단계
3 g of methyl 3-[7-chloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate and 1.9 g of 3-chloro-4-methoxybenzylamine (“A”) in 50 ml of dimethylformamide (DMF) are stirred at 60° for 12 hours in the presence of potassium carbonate. After filtration, the solvent is removed and the mixture is worked up in the customary manner. 4.6 g of methyl 3-[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl]propionate are obtained as a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06777419B1 |
| 출처 데이터셋 | uspto-grants-2004_08 |
| ORD ID | ord-7a6d2041face4b23bc606ecb3a72658d |
| 출처 메모 | uspto-grants-2004_08 |