Pyridine → 1-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

HRID 1836312노트

반응식

HRID 1836312 반응식
[NH2:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1.CS[N:22]=[C:23]=[O:24].N1C=CC=C[CH:26]=1>>[CH3:26][NH:22][C:23]([NH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[NH:5][CH:4]([C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])[CH2:3]1)=[O:24]

참가 물질

4

반응물 3

HCID 1049PyridineHCID 21933440MethylthioisocyanateHCID 234992302-(4-Amino-6-nitro-1,2,3,4-tetrahydroquinolin-2-yl)-2-methylpropan-1-ol

생성물 1

HCID 234992231-Methyl-3-[2-(2-hydroxy-1,1-dimethylethyl)-6-nitro-1,2,3,4-tetrahydroquinolin-4-yl]-urea

실험 절차

The compound of Example 22 (50 mg) and 30 mg of methyl thioisocyanate were dissolved in 1 ml of pyridine. After 2 hours of stirring at room temperature, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2) to obtain 42 mg of the title compound. Its physical properties are shown below.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (elution solvent; hexane:ethyl acetate=1:2)

출처 및 근거

ORD 기록
ord-5f5fe1c04f1041d3a3b0e8a83a2192bf
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06777427B2

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