4-Chlorobenzoyl chloride → 4-[3-(4-Chlorobenzamidyl)benzoyl]-1-methylpiperidine

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=2)[C:5]([CH:7]2[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]2)=[O:6])=[O:23])=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 85014-Chlorobenzoyl chloride

HCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

생성물 1

HCID 693561104-[3-(4-Chlorobenzamidyl)benzoyl]-1-methylpiperidine수율 109.2%

실험 절차

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (25 mg, 0.115 mmol) and 4-chlorobenzoyl chloride (29 μL, 0.229 mmol), 44.8 mg (>100%) of the title compound were recovered.

출처 및 근거

ORD 기록: ord-f816e22aaf1b45da9580873f3e4c7793
출처 데이터셋: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06777428B1

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