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Potassium Carbonate → Ethyl(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate

HRID 1836556
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HRID 1836556 반응식
[CH2:1]([O:8][C:9]1[CH:24]=[CH:23][C:12]([CH2:13][C:14]2[C:19]([CH3:20])=[CH:18][C:17]([OH:21])=[CH:16][C:15]=2[CH3:22])=[CH:11][C:10]=1[S:25]([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)(=[O:27])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:41]([O:44][CH2:45][CH2:46]Br)(=[O:43])[CH3:42].[Cl-].[NH4+]>CN(C)C=O>[CH2:45]([O:44][C:41](=[O:43])[CH2:42][O:21][C:17]1[CH:18]=[C:19]([CH3:20])[C:14]([CH2:13][C:12]2[CH:23]=[CH:24][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[C:10]([S:25]([C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)(=[O:26])=[O:27])[CH:11]=2)=[C:15]([CH3:22])[CH:16]=1)[CH3:46]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 135641-Acetoxy-2-bromoethaneHCID 25517Ammonium ChlorideHCID 234996174-{4-(Benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol

생성물 1

HCID 23499607Ethyl(4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

85 mg (0.18 mmol) of 4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenol (Example X) are dissolved in 2 ml of dimethylformamide. 30 mg (0.21 mmol) of potassium carbonate and 33 mg (0.20 mmol) of bromoethyl acetate are added. The mixture is stirred at room temperature overnight. Saturated ammonium chloride solution is then added, and the mixture is extracted three times with diethyl ether. The combined organic phases are washed three times with water, dried with sodium sulphate and concentrated under reduced pressure. This gives 80 mg (96.5% of theory) of ethyl (4-{4-(benzyloxy)-3-[(4-fluorophenyl)sulphonyl]benzyl}-3,5-dimethylphenoxy)acetate.

후처리

  1. extractionthe mixture is extracted three times with diethyl ether
  2. washThe combined organic phases are washed three times with water
  3. dry with materialdried with sodium sulphate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e2e4ab9149f448d199757c93ed68153c
출처 데이터셋
uspto-grants-2004_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06777442B2

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