Phenacyl bromide → HCID 22220743, 화합물
반응식
[CH2:1]([C:3]1[S:4][CH:5]=[C:6]([CH3:8])[N:7]=1)[CH3:2].[Br:9][CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]>C(#N)C.CCOCC>[Br-:9].[CH2:1]([C:3]1[S:4][CH:5]=[C:6]([CH3:8])[N+:7]=1[CH2:10][C:11](=[O:12])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:2]참가 물질
5
실험 절차
2-Ethyl-4-methylthiazole (0.5 g, 3.93 mmole), 2-bromo-1-phenyl-1-ethanone (0.782 g, 3.93 mmole), and acetonitrile (0.25 mL) were heated in an oil bath at 110 C. for 3 hr, then cooled, dissolved in acetonitrile (4 mL), and diluted with ether (4 mL). After storage at 4 C. overnight, the crystals which separated were filtered out and recrystalized from acetonitrile/ether to give 0.765 g of the title compound, mp 126-128.
후처리
- temperaturecooled
- customovernight, the crystals which separated
- filtrationwere filtered out
- customrecrystalized from acetonitrile/ether
출처 및 근거
- ORD 기록
- ord-6bd354f11f8447b9a55981fea6999de9
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06777557B2
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