Ethyl bromoacetate → HCID 178473177, 화합물

HRID 1836732노트

반응식

HRID 1836732 반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].[Br:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(#N)C>[Br-:9].[CH2:14]([O:13][C:11](=[O:12])[CH2:10][SH:1]1[CH:5]=[CH:4][NH+:3]=[C:2]1[CH:6]([OH:8])[CH3:7])[CH3:15]

참가 물질

4

반응물 2

HCID 7748Ethyl bromoacetateHCID 99892951-(1,3-Thiazol-2-yl)ethan-1-ol

생성물 1

HCID 178473177HCID 178473177, 화합물수율 78.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-(2-thiazolyl)ethanol (1.17 g, 8.67 mmole) and ethyl bromoacetate (1.32 g, 8.63 mmole) was heated at 48 C. for 18 hr. The reaction mixture was dissolved in acetonitrile (3 mL) and stored at 4 C. After 2 months the crystals which separated were filtered out and washed with 3:7 ether-acetonitrile to yield 2.028 g of the title compound, mp 101-103 C.

후처리

  1. temperaturewas heated at 48 C
  2. customAfter 2 months the crystals which separated
  3. filtrationwere filtered out
  4. washwashed with 3:7 ether-acetonitrile

출처 및 근거

ORD 기록
ord-18318557348147dfa7f92c4c749e9a23
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06777557B2

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