Bromoacetic Acid → HCID 22220859, 화합물
반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([OH:8])[CH3:7].[Br:9][CH2:10][C:11](O)=[O:12].C(#N)C>C(#N)C.CO>[Br-:9].[CH3:7][CH:6]1[C:2]2[S:1][CH:5]=[CH:4][N+:3]=2[CH2:10][C:11](=[O:12])[O:8]1참가 물질
5
실험 절차
1-(2-Thiazolyl)ethanol (0.5 g, 3.87 mmole), bromoacetic acid (0.537 g, 3.86 mmole), and acetonitrile (0.125 mL) were heated in an oil bath with stirring at 105 C. for 6 hr. The mixture was dissolved in 5 mL 4:1 acetonitrile/methanol and stored at 4 C. for 17 hr. The crystals which separated were filtered out and combined from two identical runs, and recrystalized from methanol/acetonitrile/ether to give a total of 0.32 g of the title compound, mp 214-215.5 C. Calcd for C7H8NO2SBr: C 33.5; H 3.20; N 5.59; found: C 33.62; H 3.16; N 5.61.
후처리
- waitfor 17 hr
- customThe crystals which separated
- filtrationwere filtered out
- customrecrystalized from methanol/acetonitrile/ether
출처 및 근거
- ORD 기록
- ord-876c05a7c0c04c07ab773ebccf6a47fe
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06777557B2
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