Dinitrofluorobenzene → N-(2,4-dinitrophenyl)-5-methyltryptamine

HRID 1837141노트

반응식

HRID 1837141 반응식
[CH3:1][C:2]1[CH:13]=[C:12]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[N+:19]([C:22]1[CH:27]=[C:26]([N+:28]([O-:30])=[O:29])[CH:25]=[CH:24][C:23]=1F)([O-:21])=[O:20]>O.C(O)C>[N+:19]([C:22]1[CH:27]=[C:26]([N+:28]([O-:30])=[O:29])[CH:25]=[CH:24][C:23]=1[NH:11][CH2:10][CH2:9][C:8]1[C:12]2[C:5](=[CH:4][CH:3]=[C:2]([CH3:1])[CH:13]=2)[NH:6][CH:7]=1)([O-:21])=[O:20]

참가 물질

6

반응물 3

HCID 6264DinitrofluorobenzeneHCID 157605-MethyltryptamineHCID 516892Sodium Bicarbonate

생성물 1

HCID 9881070N-(2,4-dinitrophenyl)-5-methyltryptamine수율 85%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

1 mMole of 5-metyltryptamine was dissolved in 100 ml of water and the pH was adjusted to pH 8.3 with 2.5 moles of sodium bicarbonate (NaHCO3), A 1.5% solution of 2,4-dinitrofluorobenzene in 200 ml ethanol was added and the mixture was stirred during 2 hours at room temperature. The desired product precipitates out, it is washed and dried. The product is obtained in 85% yield, and TLC (chloroform, silica-gel plates, reveals one yellow spot (Rf=0.8) which is well resolved from the starting materials under the same conditions.

후처리

  1. customThe desired product precipitates out
  2. washit is washed
  3. customdried
  4. customThe product is obtained in 85% yield, and TLC (chloroform, silica-gel plates

출처 및 근거

ORD 기록
ord-a2fbf7e83c0d46b6a343e10fb89c8769
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06780884B2

반응 노트

불러오는 중…