Methylamine → Methyl(3-phenoxypropyl)amine

HRID 1837268

반응식

HRID 1837268 반응식
[CH3:1][NH2:2].[O:3]([CH2:10][CH2:11][CH2:12]Br)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>O1CCCC1>[CH3:1][NH:2][CH2:12][CH2:11][CH2:10][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 6329Methylamine2회HCID 68522Benzene, (3-bromopropoxy)-

생성물 1

HCID 22067856Methyl(3-phenoxypropyl)amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3.57 g of methylamine is condensed in a solution of 1.6 ml of 3-phenoxy-propylbromide in 15 ml of anhydrous tetrahydrofuran at −78° C., and it is stirred overnight at room temperature in a pressurized reactor. After the pressurized reactor was opened at −20° C., it is allowed to come to room temperature to allow excess methylamine to evaporate off. Then, the reaction solution is added to saturated sodium chloride solution, extracted with ether, dried on magnesium sulfate and concentrated by evaporation in a vacuum. 2.01 g of methyl-(3-phenoxy-propyl)-amine is obtained as a crude product, which is used without further purification in the next stage.

후처리

  1. customwas opened at −20° C.
  2. customto come to room temperature
  3. customto evaporate off
  4. additionThen, the reaction solution is added to saturated sodium chloride solution
  5. extractionextracted with ether
  6. customdried on magnesium sulfate
  7. concentrationconcentrated by evaporation in a vacuum

출처 및 근거

ORD 기록
ord-fc7b3c344a2b4cff8abb4059c487e8b0
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06780855B2

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