Thionyl Chloride → 4-Chloro-7-fluoroquinoline-3-carbonitrile
반응식
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](O)=[C:7]([C:12]#[N:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>CN(C)C=O>[Cl:17][C:6]1[C:5]2[C:10](=[CH:11][C:2]([F:1])=[CH:3][CH:4]=2)[N:9]=[CH:8][C:7]=1[C:12]#[N:13]참가 물질
4
실험 절차
A mixture of 7-fluoro-4-hydroxyquinoline-3-carbonitrile (2.02 g, 10.7 mmol) and a few drops of N, N-dimethylformamide in 16.0 mL of thionyl chloride is heated at reflux for 1.5 h. The reaction mixture was concentrated in vacuo and toluene (20 mL) is added and the mixture is again concentrated in vacuo to provide 2.18 g of 4-chloro-7-fluoroquinoline-3-carbonitrile as a yellow solid, mp 163-165° C.
후처리
- temperatureis heated
- temperatureat reflux for 1.5 h
- concentrationThe reaction mixture was concentrated in vacuo and toluene (20 mL)
- additionis added
- concentrationthe mixture is again concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-674890530a6e46b996d9f71949040f65
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06780996B2
반응 노트
불러오는 중…