4-Chloro-5-methylthieno[2,3-d]pyrimidine → 4-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine

HRID 1837471노트

반응식

HRID 1837471 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl[C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1>C(O)(C)C>[CH3:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[CH:13]=2)=[O:11])=[CH:3][C:2]=1[NH:1][C:25]1[C:26]2[C:33]([CH3:34])=[CH:32][S:31][C:27]=2[N:28]=[CH:29][N:30]=1

참가 물질

4

반응물 2

HCID 2902254-Chloro-5-methylthieno[2,3-d]pyrimidineHCID 17904941N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide

생성물 1

HCID 99121024-[2-Methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]-5-methylthieno[2,3-d]pyrimidine수율 25.4%

시약·촉매·용매 1

HCID 3776Isopropanol용매

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온도
88 °C

실험 절차

N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide (0.056 g), 4-chloro-5-methylthieno[2,3-d]pyrimidine (Maybridge Chemical Company, Trevillet, Tintagel, Cornwall, PL34 0HW, GB; 0.037 g) and isopropanol (2 ml) and the reaction mixture was stirred and heated to 88° C. for 18 hours. The reaction mixture was cooled to ambient temperature and the precipitate was isolated and washed in turn with isohexane and diethyl ether. There was thus obtained the title compound (0.021 g); Mass: M+H+ 461.

후처리

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. customthe precipitate was isolated
  3. washwashed in turn with isohexane and diethyl ether

출처 및 근거

ORD 기록
ord-9ee3689c8f5440d0a2f65b0cd3e41f3d
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784174B1

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