Water → 2-bromo-1-(2,3-dihydro-1H-inden-2-yl)ethan-1-one
반응식
[Br:1]Br.[C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)(=[O:5])[CH3:4].O>CO>[Br:1][CH2:4][C:3]([CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5]참가 물질
5
실험 절차
10 g of pure bromine are rapidly added at 0° C. to a solution of 10 g of 2-acetylindane in 150 ml of anhydrous methanol. After one hour at ambient temperature, 100 ml of water are added and the whole is stirred for 12 hours. After extracting twice with 200 ml of diethyl ether each time, and washing the organic phase with a sodium hydrogen carbonate solution and then with water, the expected product is dried over magnesium sulphate and concentrated.
후처리
- extractionAfter extracting twice with 200 ml of diethyl ether each time
- washwashing the organic phase with a sodium hydrogen carbonate solution
- dry with materialwith water, the expected product is dried over magnesium sulphate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d2f3c070e3ad453590716dc0f62b1c51
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06784183B2
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