Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate → Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

HRID 1837698노트

반응식

HRID 1837698 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][C:13](=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 2

HCID 22678611Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22678708Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-4-piperidyl]acetate

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

2.6 g of ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate and 380 mg of 10% palladium-carbon powder (water-containing product) were suspended in 20 ml of ethyl acetate. After replacing the atmosphere of a container with hydrogen, the mixture was stirred at room temperature under normal pressure for one hour. The reaction solution was filtered, and the filtrate was evaporated, to give the title compound as a yellow oil (quantitatively).

후처리

  1. filtrationThe reaction solution was filtered
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-dbcbbeefeab445ea88f19733d65a9076
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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