Dimethylformamide → 2-(2-Methoxypyridin-3-yl)acetonitrile

HRID 1837702노트

반응식

HRID 1837702 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9]Cl)=[CH:7][CH:6]=[CH:5][N:4]=1.[C-]#N.[Na+].[CH3:14][N:15](C=O)C>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:14]#[N:15])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 149329453-(Chloromethyl)-2-methoxypyridine

생성물 1

HCID 226785372-(2-Methoxypyridin-3-yl)acetonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4 g of (2-methoxy-3-pyridyl)methyl chloride, 2.5 g of sodium cyanide and 10 ml of DMF were stirred under heating for 10 minutes. Water was added thereto, and the mixture was extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The drying agent was removed, and the solvent was evaporated. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1), to give 2.5 g of a colorless oil.

후처리

  1. temperatureunder heating for 10 minutes
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe drying agent was removed
  5. customthe solvent was evaporated
  6. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1)

출처 및 근거

ORD 기록
ord-f1231a14f7534ee4895c0a159a0db220
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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