Methanol → 1-[(2-Methoxy-3-pyridyl)methyl]-4-[2-(2-aminophenyl)-2-oxoethyl]piperidine

HRID 1837738노트

반응식

HRID 1837738 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17](=[O:31])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24]C(=O)C(F)(F)F)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+].CO>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH2:24])=[O:31])[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 226786181-[(2-Methoxy-3-pyridyl)methyl]-4-[2-oxo-2-(2-trifluoroacetylaminophenyl)ethyl]piperidine

생성물 1

HCID 226784371-[(2-Methoxy-3-pyridyl)methyl]-4-[2-(2-aminophenyl)-2-oxoethyl]piperidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

150 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[2-oxo-2-(2-trifluoroacetylaminophenyl)ethyl]piperidine obtained in Example 63 and 141 mg of potassium carbonate were suspended in a mixed solvent of 3 ml of methanol and 3 ml of water, and the mixture was stirred at room temperature for one hour. The reaction solution was extracted with ethyl acetate, and the organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound as a yellow oil (quantitatively).

후처리

  1. extractionThe reaction solution was extracted with ethyl acetate
  2. washthe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-eefd2cbd4dc849369a64e71bdc1c7900
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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