홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Dimethylformamide → N1-(3-Fluorobenzyl)-2-[1-[2-[1-(cyclopropylmethyl)-2-oxo-1,2-dihydro-3-pyridinyl]ethyl]-2-piperidyl]acetamide

HRID 1837758
노트
인쇄 미리보기

반응식

HRID 1837758 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][NH:6][C:7](=[O:24])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH2:15][CH2:16][C:17]1[C:18](=[O:23])[NH:19][CH:20]=[CH:21][CH:22]=1.[CH:28]1([CH2:31]Cl)[CH2:30][CH2:29]1.C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[F:1][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][CH:27]=1)[CH2:5][NH:6][C:7](=[O:24])[CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][N:10]1[CH2:15][CH2:16][C:17]1[C:18](=[O:23])[N:19]([CH2:31][CH:28]2[CH2:30][CH2:29]2)[CH:20]=[CH:21][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropaneHCID 22678298N1-(3-Fluorobenzyl)-2-[1-[2-(2-oxo-1,2-dihydro-3-pyridinyl)ethyl]-2-piperidyl]acetamide

생성물 1

HCID 22678543N1-(3-Fluorobenzyl)-2-[1-[2-[1-(cyclopropylmethyl)-2-oxo-1,2-dihydro-3-pyridinyl]ethyl]-2-piperidyl]acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

230 mg of N1-(3-fluorobenzyl)-2-[1-[2-(2-oxo-1,2-dihydro-3-pyridinyl)ethyl]-2-piperidyl]acetamide obtained in Example 198, 0.08 ml of cyclopropylmethyl chloride, 450 mg of potassium carbonate and 5 ml of DMF were stirred at 60° C. for 1 hour. Water was added thereto, and the mixture was extracted with ethyl acetate. The extract was dried over sodium sulfate. The drying agent was filtered off, and the solvent was evaporated. The residue was purified by NH-silica gel column chromatography (hexane:ethyl acetate=1:1, subsequently ethyl acetate), to give 180 mg of a colorless oil.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over sodium sulfate
  3. filtrationThe drying agent was filtered off
  4. customthe solvent was evaporated
  5. customThe residue was purified by NH-silica gel column chromatography (hexane

출처 및 근거

ORD 기록
ord-67a8a4aa8c98467b876e4634ec38b19c
출처 데이터셋
uspto-grants-2004_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06784192B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트