Methylamine → Amlodipine

HRID 1837799노트

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HRID 1837799 반응식
[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][N:28]1C(=O)C2C(=CC=CC=2)C1=O)=[O:5].CN>>[CH3:1][CH2:2][O:3][C:4]([C:6]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]([C:19]([O:21][CH3:22])=[O:20])=[C:9]([CH3:23])[NH:8][C:7]=1[CH2:24][O:25][CH2:26][CH2:27][NH2:28])=[O:5]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 9871958Phthalimidoamlodipine

생성물 1

HCID 2162Amlodipine

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온도
0 °C

실험 절차

Phthaloyl amlodipine (100 g, 0.18 M) was reacted with monomethyl amine (500 g, 40% solution) in denatured spirit at room temperature for 8 hrs, cooled to 0° C., filtered, washed with distilled water up to neutral pH and dried at 60-65° C. for 8 ills. Yield 58 g.

후처리

  1. filtrationfiltered
  2. washwashed with distilled water up to neutral pH
  3. customdried at 60-65° C. for 8 ills

출처 및 근거

ORD 기록
ord-0446c85fbae1475e863fd016fb81c07c
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784297B2

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