1-Phenylpyrrolidine → HCID 86588398, 화합물

HRID 1837842노트

반응식

HRID 1837842 반응식
[C:1]1([N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][O:13][C:14](=[O:19])[CH:15]=[CH:16][CH:17]=[O:18].C([C@@H]1N[C@H](C(C)(C)C)N(C)C1=O)C1C=CC=CC=1>>[CH3:12][O:13][C:14](=[O:19])[C@@H:15]([C:4]1[CH:5]=[CH:6][C:1]([N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)=[CH:2][CH:3]=1)[CH2:16][CH:17]=[O:18]

참가 물질

4

반응물 3

HCID 777261-PhenylpyrrolidineHCID 111293Methyl 4-oxobut-2-enoateHCID 103098345-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone, (2S,5S)-

생성물 1

HCID 86588398HCID 86588398, 화합물

실험 절차

This example describes a Friedel-Crafts alkylation reaction of 1-phenyl-pyrrolidine and 4-oxo-butenoic acid methyl ester, catalyzed by the hydrochloride salt of (1), to provide (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester.

출처 및 근거

ORD 기록
ord-c5d357304ae04caba5265fbaf7e33a6a
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784323B2

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