4-Fluorophenyl 2-thienyl ketone → (4-Fluorophenyl)(2-thienyl)methanol
반응식
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[O:7])=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH:6]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[OH:7])=[CH:4][CH:3]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 2-(4-fluorobenzoyl)thiophene (5.09 g, 24.7 mmol) in Et2O (100 mL) was added a solution of LiAlH4 (1M in THF, 30 mL, 30 mmol) and the reaction mixture was stirred overnight. The resulting mixture was cooled to 0° C., poured onto ice, extracted with Et2O, dried (Na2SO4) and concentrated under reduced pressure to give (4-fluorophenyl)-2-thienylmethan-1-ol as a yellow oil. The crude product was used without further purification.
후처리
- additionpoured onto ice
- extractionextracted with Et2O
- dry with materialdried (Na2SO4)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-570da4342e30423b8dc7efde5d17f5b9
- 출처 데이터셋
- uspto-grants-2004_08
- 특허 번호
- US06784167B2
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