Chlorotrimethylsilane → HCID 22677668, 화합물

HRID 1837962노트

반응식

HRID 1837962 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.CCN(CC)CC.[CH3:20][Si:21](Cl)([CH3:23])[CH3:22]>C1COCC1>[CH3:20][Si:21]([CH3:23])([CH3:22])[O:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 35641974-Thiophen-2-ylphenol

생성물 1

HCID 22677668HCID 22677668, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-(2-thienyl)phenol in anhyd. THF (10 mL) was added Et3N (0.9 mL, 6.5 mmol), followed by TMSCl (0.4 mL, 3.2 mmol). The reaction mixture was stirred at room temperature overnight, then filtered and concentrated under reduced pressure to give 2-(4-trimethylsilyloxyphenyl)thiophene: TLC (20% EtOAc/hex) Rf 0.69. This material was used without further purification.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-798e47486a944d268588d2a9290458af
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784167B2

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