Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride | HCID 197747 | — |
| 반응물 | 4-Chloro-2,6-bis[(2-hydroxyethyl)amino]pyrimidine-5-carbonitrile | HCID 18753217 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile | HCID 18753262 | — |
반응 단계
In analogy to the procedure described in example 20 (2), the 4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile was treated with the 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride in dioxane in the presence of N-ethyl-diisopropylamine at 60° C. to yield the 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as an amorphous, white solid; MS: [M+H]+=399.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06673795B2 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-e795bebcdd9c47ca81c2b21caa9db260 |
| 출처 메모 | uspto-grants-2004_01 |