Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Mepp → 1-[4-(3-Phenyl-4,5-dihydroisoxazol-5-yl)butyl]-4-(2-methylphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Mepp | HCID 91965 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 4-(3-Phenyl-4,5-dihydroisoxazol-5-yl)butanal | HCID 18753392 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-[4-(3-Phenyl-4,5-dihydroisoxazol-5-yl)butyl]-4-(2-methylphenyl)piperazine | HCID 10293003 | 67.3% |
반응 단계
4-(3-Phenyl-4,5-dihydroisoxazol-5-yl)butanal (27.1 mg, 0.124 mmol), 1-(o-tolyl) piperazine (20.0 mg, 0.113 mmol), molecular sieve (5 beads) and NaBH(OAc)3 (72.1 mg, 0.340 mmol) were reacted in 3 mL of methylene chloride for about 12 hr. With the following processes the same as in Example 1, 26.5 mg (67.3%) of the target compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06673800B2 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-becf27c4ea2743eb97e8a45c23f090b0 |
| 출처 메모 | uspto-grants-2004_01 |