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Water → 1-Benzenesulfonyl-5-methanesulfonyl-2-([1,3,4]oxadiazol-2-yl)indole

HRID 1838320
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HRID 1838320 반응식
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15](SC)=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:21]2[O:22][CH:23]=[N:24][N:25]=2)(=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[O:27][S:28]([O-:30])=O.[K+].[OH2:32].O1CCC[CH2:34]1>>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([S:28]([CH3:34])(=[O:30])=[O:27])=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:21]2[O:22][CH:23]=[N:24][N:25]=2)(=[O:8])=[O:32])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 225044011-benzenesulfonyl-5-methylthio-2-([1,3,4]oxadiazol-2-yl)-1H-indoleHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 225044261-Benzenesulfonyl-5-methanesulfonyl-2-([1,3,4]oxadiazol-2-yl)indole

반응 조건

온도
0 °C

실험 절차

To a solution of the compound obtained in Example 4 (1) (265 mg) in tetrahydrofuran (7 ml), an aqueous solution (3.5 ml) of OXONE (registered trademark) (970 mg) was added dropwise and the mixture was stirred at 0° C. for 4 hours. To the reaction solution was added water, the mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was separated using silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain 262 mg of the desired product.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was separated

출처 및 근거

ORD 기록
ord-d186825965854cc2a9c64aac93b02cbf
출처 데이터셋
uspto-grants-2004_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06673797B1

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