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Water → 1-Benzenesulfonyl-2-(2-ethoxycarbonylfuran-5-yl-methyl)-5-methanesulfonylindole

HRID 1838384
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인쇄 미리보기

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HRID 1838384 반응식
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15](SC)=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:21][C:22]2[O:26][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:24][CH:23]=2)(=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[O:33][S:34]([O-:36])=O.[K+].[C:38](=O)([O-])O.[Na+].[OH2:43]>O1CCCC1>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([S:34]([CH3:38])(=[O:36])=[O:33])=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:21][C:22]2[O:26][C:25]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:24][CH:23]=2)(=[O:8])=[O:43])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 225044301-Benzenesulfonyl-2-(2-ethoxycarbonylfuran-5-yl-methyl)-5-methylthioindoleHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 225044421-Benzenesulfonyl-2-(2-ethoxycarbonylfuran-5-yl-methyl)-5-methanesulfonylindole

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

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온도
22.5 °C

실험 절차

To a solution of the compound obtained in Example 30 (3) (0.183 g) in a mixture of tetrahydrofuran (2 ml) and water (2 ml), OXONE (registered trademark) (0.4939 g) was added under ice-cooling and the mixture was stirred for 30 minutes and at 15 to 30° C. for 1.5 hours. A saturated aqueous sodium hydrogencarbonate solution was added thereto, and the mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was separated using silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain 0.1722 g of the desired product.

후처리

  1. additionwas added under ice-
  2. temperaturecooling
  3. extractionthe mixture was extracted with ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe resulting residue was separated

출처 및 근거

ORD 기록
ord-bab89a9b5f0649f2866dc7f331e6a5b0
출처 데이터셋
uspto-grants-2004_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06673797B1

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