Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Uracil → Benzyl chloromethyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Uracil | HCID 1174 | — |
| 반응물 | 6-(Trifluoromethyl)uracil | HCID 233890 | — |
| 반응물 | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| 생성물 | Benzyl chloromethyl ether | HCID 137983 | — |
반응 단계
In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-trifluoromethylpyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 48%) as a colorless oil. 1H-Nuclear magnetic resonance spectrum (270 MHz, CDCl3) δ ppm: 8.84 (1H, br.s), 6.24 (1H, d, J=2 Hz), 5.32 (2H, s), 3.73-3.68 (2H, m), 0.97-0.90 (2H, m), 0.01 (9H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06673804B1 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-4e3eda8a0b684396a66041b38523872a |
| 출처 메모 | uspto-grants-2004_01 |