Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Cyanide → (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 4-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 118642 | — |
| 반응물 | Tosylmethyl isocyanide | HCID 161915 | — |
| 생성물 | (4R *,5R*)-5-(4-chloro-3-trifluoromethyl-phenyl)-4-(toluene-4-sulfonyl)-4,5-dihydro-oxazole | HCID 69556945 | — |
반응 단계
In a manner analogous to Preparation 1, 4-chloro-3-(trifluoromethyl)benzaldehyde (0.31 g, 1.47 mmol), tosylmethylisocyanide (0.27 g, 1.40 mmol) and NaCN (6.9 mg, 0.14 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 404.5 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06673941B2 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-00720582f38548ef90c33263ef810705 |
| 출처 메모 | uspto-grants-2004_01 |