Pyridine → HCID 15858643, 화합물

HRID 1838896노트

반응식

HRID 1838896 반응식
[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][OH:10].N1C=CC=CC=1.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1>O>[S:28]([C:25]1[CH:26]=[CH:27][C:22]([CH3:32])=[CH:23][CH:24]=1)([O:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]([F:15])([F:1])[C:11]([F:12])([F:13])[F:14])(=[O:30])=[O:29]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 113682968,8,9,9,9-Pentafluorononan-1-ol

생성물 1

HCID 15858643HCID 15858643, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3.0 g of 8,8,9,9,9-pentafluorononan-1-ol are dissolved in 26 ml of abs. pyridine, 3.1 g of p-toluenesulphonyl chloride are added at 0° C. and the mixture is stirred in the cold for 1.5 hours. The reaction mixture is then added to water, extracted 3 times with ether, dried over magnesium sulphate and concentrated in vacuo. Preparative column chromatography on silica gel using a hexane-ethyl acetate gradient leads to 4.1 g of 8,8,9,9,9-pentafluorononyl tosylate as a clear oil.

후처리

  1. extractionextracted 3 times with ether
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-1b89c1439cb049c98fd5cdc8b513aae0
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677324B1

반응 노트

불러오는 중…