Methylamine → N-Methyl-2-(p-tolyl)ethanamine

HRID 1838920노트

반응식

HRID 1838920 반응식
[CH3:1][NH2:2].S(C1C=CC(C)=CC=1)(O[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)(=O)=O>O1CCCC1>[CH3:1][NH:2][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 6329Methylamine2회HCID 2853862-(4-Methylphenyl)ethyl 4-methylbenzenesulfonate

생성물 1

HCID 22898654N-Methyl-2-(p-tolyl)ethanamine수율 180.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

9.2 g of methylamine are condensed at −20° C. into a solution of 5.8 g of 2-p-tolylethyl tosylate in 15 ml of abs. tetrahydrofuran and the mixture is stirred overnight at room temperature in a pressure vessel. After the pressure vessel has been opened at −20° C., it is allowed to come to room temperature in order to allow excess methylamine to evaporate. The reaction solution is taken up in ether, washed with water and saturated sodium chloride solution, dried over magnesium sulphate and concentrated to dryness in vacuo. 5.39 g of methyl-(2-p-tolylethyl)amine are obtained, which is reacted further as a crude product.

후처리

  1. customhas been opened at −20° C.
  2. customto come to room temperature in order
  3. customto evaporate
  4. washwashed with water and saturated sodium chloride solution
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated to dryness in vacuo

출처 및 근거

ORD 기록
ord-b35780ae1b2b434e9cd9b2a11ab538f2
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677324B1

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