Ammonia methanol → 7-Sulfamoylimidazo[5,1-b]thiazole
반응식
[NH3:1].CO.Cl[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])=[O:6]>C1COCC1>[S:5]([C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)(=[O:7])(=[O:6])[NH2:1]참가 물질
4
실험 절차
A 2 M ammonia/methanol solution, (4 ml) was added to a solution of 0.44 g of 7-chlorosulfonylimidazo[5,1-b]thiazole in 10 ml of THF. The mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated. The residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1) to give 0.34 g of 7-sulfamoylimidazo[5,1-b]thiazole.
후처리
- concentrationThe reaction mixture was concentrated
- customThe residue was purified by column chromatography on silica gel (dichloromethane:methanol=10:1)
출처 및 근거
- ORD 기록
- ord-a54c390459e14ef497080825af863b89
- 출처 데이터셋
- uspto-grants-2004_01
- 특허 번호
- US06677331B2
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