Trifluoroacetic acid → (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide

HRID 1839839노트

반응식

HRID 1839839 반응식
C(OC([N:8]1[CH2:12][C@H:11]([OH:13])[CH2:10][C@@H:9]1[C:14](=[O:19])[NH:15][CH:16]1[CH2:18][CH2:17]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:16]1([NH:15][C:14]([C@H:9]2[CH2:10][C@@H:11]([OH:13])[CH2:12][NH:8]2)=[O:19])[CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69741572(2R,4R)-2-cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 28943484(2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide수율 95.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(2R,4R)-2-Cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5 g) was deprotected using 50 mL of 30% TFA in DCM at rt for 2 hours to give 3 g of (2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide as a light yellow oil.

후처리

  1. customat rt
  2. customfor 2 hours

출처 및 근거

ORD 기록
ord-32eceb6df9d34c85af99f07d0247bcf0
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677368B2

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