Aluminium lithium hydride → HCID 69741629, 화합물

HRID 1839840노트

반응식

HRID 1839840 반응식
[CH:1]1([NH:4][C:5]([C@H:7]2[CH2:11][C@@H:10]([OH:12])[CH2:9][NH:8]2)=O)[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]1([NH:4][CH2:5][C@@H:7]2[NH:8][CH2:9][C@H:10]([OH:12])[CH2:11]2)[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 28943484(2R,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide

생성물 1

HCID 69741629HCID 69741629, 화합물수율 36.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide (3 g) was reduced using LAH (2 g) in THF (150 mL) to give 1 g of (3R,5R)-5-cyclopropylaminomethyl-pyrrolidin-3-ol.

출처 및 근거

ORD 기록
ord-c32683831be941fb9b1c6cd2517ca032
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677368B2

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