(Z)-Benzaldehyde oxime → Methyl 3-phenylisoxazole-4-carboxylate

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1.C(=NO)C1C=CC=CC=1>>[C:5]1([C:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][O:10][N:9]=2)[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

참가 물질

반응물 2

HCID 12143(Z)-Benzaldehyde oxime

HCID 870083HCID 870083, 화합물

생성물 1

HCID 10750662Methyl 3-phenylisoxazole-4-carboxylate수율 35%

실험 절차

This compound was synthesised following the procedure described for Compound 8C but using benzaldoxime instead of 4-fluorobenzaldoxime as a starting material. The crude was purified twice by flash chromatography (toluene-acetone 96:4 followed by toluene) to give the title compound as an oil (35%).

후처리

customThis compound was synthesised
customThe crude was purified twice by flash chromatography (toluene-acetone 96:4 followed by toluene)

출처 및 근거

ORD 기록: ord-9e46f34d1f4a4772bc239ff417afeb61
출처 데이터셋: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06680319B2

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