Triethylamine → 3-Chloro-2-fluorophenylisothiocyanate

HRID 1840356노트

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HRID 1840356 반응식
[F:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(CC)CC)C.C(OCC)(=O)C>C1(C)C=CC=CC=1.O>[F:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 10040ThiophosgeneHCID 750143-Chloro-2-fluoroaniline

생성물 1

HCID 27575833-Chloro-2-fluorophenylisothiocyanate수율 74%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

Into a solution of 2-fluoro-3-chloroaniline (1.0 g, 6.87 mmol) in 30 mL of toluene at room temperature, thiophosgene (0.8 mL, 10.3 mmol) and triethylamine (1.12 mL, 8.24 mmol) were added. The mixture was stirred at room temperature for 16 hours. The mixture was parationed between ethyl acetate and water. The combined organic layer was then concentrated to give the desired product (950 mg, 74%). 1H NMR (CDCl3) δ 7.09 (m, 2H), 7.30 (m, 1H).

후처리

  1. concentrationThe combined organic layer was then concentrated

출처 및 근거

ORD 기록
ord-68cb9c62588f4f9db7166c3fd3d9f919
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06680317B2

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