Triethylamine → 3-fluoro-2-methylphenylisothiocyanate
반응식
[CH3:1][C:2]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:1][C:2]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]참가 물질
5
실험 절차
Into a solution of 2-methyl-3-fluoroaniline (1.0 g, 8.0 mmol) in 30 mL of toluene at room temperature, thiophosgene (0.94 mL, 12 mmol) and triethylamine (1.34 mL, 12 mmol) was added. The mixture was stirred at room temperature for 16 hours. The mixture was partitioned between ethyl acetate and water. The combined organic layer was then concentrated to give the desired product (1.1 g, 82%). EI-MS m/z 168.2 (M+).
후처리
- customThe mixture was partitioned between ethyl acetate and water
- concentrationThe combined organic layer was then concentrated
출처 및 근거
- ORD 기록
- ord-29631824a64d4a1494f487d135d9e8d5
- 출처 데이터셋
- uspto-grants-2004_01
- 특허 번호
- US06680317B2
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