Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1840479생성일: 2026년 10월 26일
Piperidine → 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide
https://huagongshe.com/reaction/1840479
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 반응물 | N-methyl-2-oxoindoline-5-sulfonamide | HCID 10176909 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide | HCID 54565082 | 70% |
반응 단계
A mixture of 5-methylaminosulfonyl-2-oxindole (90 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 90 mg (70% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (mixture of isomers).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06680335B2 |
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| 출처 데이터셋 | uspto-grants-2004_01 |
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| ORD ID | ord-9dcaf09da6084b1dacc6d3ce33d6b17d |
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| 출처 메모 | uspto-grants-2004_01 |
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