Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1840483생성일: 2026년 10월 27일
Piperidine → 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid
https://huagongshe.com/reaction/1840483
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 반응물 | 2-Oxindole-5-carboxylic acid | HCID 2773318 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid | HCID 54138555 | 67% |
반응 단계
A mixture of 5-carboxy-2-oxindole (113 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 75 mg (58% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid (piperidine salt).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06680335B2 |
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| 출처 데이터셋 | uspto-grants-2004_01 |
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| ORD ID | ord-97a6ac677a4b4088b7bc8b15385eb644 |
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| 출처 메모 | uspto-grants-2004_01 |
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