Benzene, (2-iodoethyl)- → 6-Acetyl-4,4-dimethyl-1-(2-phenylethyl)-3,4-dihydroquinolin-2(1H)-one

반응식

[CH2:1]([N:7]1[C:16]2[C:11](=[CH:12][C:13]([C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=2)[C:10]([CH3:21])([CH3:20])[CH2:9][C:8]1=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].I[CH2:24][CH2:25]C1C=CC=CC=1>>[C:3]1([CH2:2][CH2:1][N:7]2[C:16]3[C:11](=[CH:12][C:13]([C:17](=[O:19])[CH3:18])=[CH:14][CH:15]=3)[C:10]([CH3:21])([CH3:20])[CH2:9][C:8]2=[O:22])[CH:25]=[CH:24][CH:6]=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 28503Benzene, (2-iodoethyl)-

HCID 121354162(1H)-Quinolinone, 6-acetyl-1-hexyl-3,4-dihydro-4,4-dimethyl-

생성물 1

HCID 698908836-Acetyl-4,4-dimethyl-1-(2-phenylethyl)-3,4-dihydroquinolin-2(1H)-one수율 34%

실험 절차

Following a procedure similar to that used for the preparation of Intermediate 6a but using (2-iodo-ethyl)benzene as the alkylating reagent the title compounds was obtained as a colorless oil (34% yield).

출처 및 근거

ORD 기록: ord-f3dedc273e0c4c39bd421954b290e39d
출처 데이터셋: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06683092B1

반응 노트

불러오는 중…