Tert-butyl 4-(benzyloxy)benzoate → tert-Butyl 4-hydroxybenzoate

HRID 1840941

반응식

HRID 1840941 반응식
[C:1]([O:5][C:6](=[O:21])[C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6](=[O:21])[C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 53864121Tert-butyl 4-(benzyloxy)benzoate

생성물 1

HCID 117640tert-Butyl 4-hydroxybenzoate수율 95%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

0.36 g of 10% palladium on activated carbon were added to a solution of 1.2 g (4.3 mmol) of 4-benzyloxy-benzoic acid tert-butyl ester in 45 mL of ethanol and this mixture was hydrogenated at 20 psi for 3 hours. After filtering over celite and removing the solvent under reduced pressure 0.79 g (95% yield) of 4-hydroxy-benzoic acid tert-butyl ester were obtained.

후처리

  1. filtrationAfter filtering over celite

출처 및 근거

ORD 기록
ord-088307d29382438e849941b901475049
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683096B2

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