1-Phenylpiperazine → 1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazine

HRID 1841469

반응식

HRID 1841469 반응식
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:22])OC2C=CC=CC=2)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[C:23]1([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:30][CH2:31]2)=[O:22])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

참가 물질

5

반응물 3

HCID 70961-PhenylpiperazineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 23446261Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate

생성물 1

HCID 234463101-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazine수율 76.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate (378 mg, 1.28 mmol) and 1-phenylpiperazine (208 mg, 1.28 mmol) were dissolved in anhydrous tetrahydrofuran and thereto DBU (195 mg, 1.28 mmol) was added. The mixture was stirred at room temperature for 2 hours, concentrated under the reduced pressure to remove the solvent, and purified by column chromatography to obtain the titled compound.

후처리

  1. concentrationconcentrated under the reduced pressure
  2. customto remove the solvent
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-e7f5406943b0490c94103ffa25628ee8
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683184B2

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