1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dinitrophenyl)piperazine → 1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-diami-nophenyl) piperazine

HRID 1841481노트

반응식

HRID 1841481 반응식
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([N+:28]([O-])=O)[CH:25]=[C:24]([N+:31]([O-])=O)[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[C:26]([NH2:28])[CH:25]=[C:24]([NH2:31])[CH:23]=3)[CH2:18][CH2:17]2)=[O:15])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

참가 물질

4

반응물 1

HCID 234462621-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dinitrophenyl)piperazine

생성물 1

HCID 234463111-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-diami-nophenyl) piperazine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-dinitrophenyl)piperazine (200 mg, 0.44 mmol) was dissolved in ethanol (30 ml) and thereto 10% palladium/carbon (10 mg) was added. The mixture was hydrogenated for 4 hours, and then filtered to remove the 10% palladium/carbon. The filtrate was concentrated and purified by column chromatography to obtain the titled compound.

후처리

  1. filtrationfiltered
  2. customto remove the 10% palladium/carbon
  3. concentrationThe filtrate was concentrated
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-e86520a9d7554805851f5ec41bec1c83
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683184B2

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