1-(2-Methoxyphenyl)piperazine → HCID 86588090, 화합물

HRID 1841486

반응식

HRID 1841486 반응식
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[S:22])OC2C=CC=CC=2)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:34]2[CH2:33][CH2:32][N:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[O:24][CH3:23])[CH2:36][CH2:35]2)=[S:22])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

참가 물질

5

반응물 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 53676590Phenyl N-(2-methoxyquinoxalin-3-yl)thiocarbamate

생성물 1

HCID 86588090HCID 86588090, 화합물수율 62.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Phenyl N-(2-methoxyquinoxalin-3-yl)thiocarbamate (215 mg, 0.69 mmol) and 1-(2-methoxyphenyl)piperazine (154 mg, 0.69 mmol) were dissolved in anhydrous tetrahydrofuran (25 ml) and thereto DBU (105 mg, 0.69 mmol) was added. The mixture was stirred at room temperature for 2 hours, concentrated under the reduced pressure to remove the solvent and purified by column chromatography to obtain the titled compound.

후처리

  1. concentrationconcentrated under the reduced pressure
  2. customto remove the solvent
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-24815aa18f7d4582b7bea717727f8a32
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06683184B2

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