Azepane-4-carboxylic acid → 1-[(S)-4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-azepane-4-carboxylic acid

HRID 1842009

반응식

HRID 1842009 반응식
COC(=O)C1C=CC([CH:10]2C[N:12]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C@@H:21]4[O:26][C:25]5[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=5[O:23][CH2:22]4)=[CH:17][CH:16]=3)[CH2:11]2)=CC=1.N1[CH2:38][CH2:37][CH2:36][CH:35]([C:39]([OH:41])=[O:40])CC1>>[O:26]1[C:25]2[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=2[O:23][CH2:22][C@@H:21]1[C:18]1[CH:17]=[CH:16][C:15]([CH2:14][N:12]2[CH2:38][CH2:37][CH2:36][CH:35]([C:39]([OH:41])=[O:40])[CH2:10][CH2:11]2)=[CH:20][CH:19]=1

참가 물질

3

반응물 2

HCID 20139928Azepane-4-carboxylic acidHCID 866953634-{1-[(S)-4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-azetidin-3-yl}-benzoic acid methyl ester

생성물 1

HCID 717374731-[(S)-4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-azepane-4-carboxylic acid

실험 절차

Compound 266 is synthesized from Intermediate A and azepane-4-carboxylic acid according to General Method B. (LC/MS method 16: ES+ m/z 368.3 [M+H]+, Rt=2.76 min)

출처 및 근거

ORD 기록
ord-41cdc40ebc724293b8a6a4508d62a30a
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946203B2

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