3-Acetylphenylboronic acid → N-[5-(3-acetylphenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

HRID 18423

반응식

HRID 18423 반응식
I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([NH:11][S:12]([CH:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH2:5]2.[C:18]([C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1)(=[O:20])[CH3:19]>>[C:18]([C:21]1[CH:26]=[C:25]([C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[CH2:7][CH:6]([NH:11][S:12]([CH:15]([CH3:17])[CH3:16])(=[O:14])=[O:13])[CH2:5]3)[CH:24]=[CH:23][CH:22]=1)(=[O:20])[CH3:19]

참가 물질

3

반응물 2

HCID 27343103-Acetylphenylboronic acidHCID 46899809N-(5-iodo-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

생성물 1

HCID 11689005N-[5-(3-acetylphenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

실험 절차

The title compound was prepared from Intermediate 2 and (3-acetylphenyl)boronic acid (Sigma Aldrich Company Ltd.) using the method of Example 1; mass spectrum (API+): Found 358 (MH+), C20H23NO3S requires 357; 1H-NMR (400 MHz, CDCl3): 1.42 (6H, d, J=7 Hz), 2.66 (3H, s), 2.99 (2H, m), 3.20 (1H, m), 3.35 (2H, m), 4.29 (2H, m), 7.32 (1H, m), 7.46 (2H, m), 7.56 (1H, m), 7.76 (1H, m), 7.92 (1H, m), 8.14 (1H, m).

출처 및 근거

ORD 기록
ord-88d727a6626a46cbb465620735f1087c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741351B2

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