Tert-butyl 3-(2-amino-4-methylphenylcarbamoyl)azetidine-1-carboxylate → HCID 178423469, 화합물

HRID 1842487노트

반응식

HRID 1842487 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH:12]1[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13]1)=O.NC1C=CC(C)=CC=1NC(C1CN(C(OC(C)(C)C)=O)C1)=O>CC(O)=O>[CH3:8][C:6]1[CH:5]=[CH:4][C:3]2[NH:9][C:10]([CH:12]3[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13]3)=[N:1][C:2]=2[CH:7]=1

참가 물질

4

반응물 2

HCID 58548457Tert-butyl 3-(2-amino-4-methylphenylcarbamoyl)azetidine-1-carboxylateHCID 58548488Tert-butyl 3-(2-amino-5-methylphenylcarbamoyl)azetidine-1-carboxylate

생성물 1

HCID 178423469HCID 178423469, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A solution of tert-butyl 3-(2-amino-4-methylphenylcarbamoyl)azetidine-1-carboxylate and tert-butyl 3-(2-amino-5-methylphenylcarbamoyl)azetidine-1-carboxylate (prepared in the previous step) in AcOH (40 mL) was heated to 100° C. for 1.5 h and concentrated. The product tert-butyl 3-(5-methyl-1H-benzo[d]imidazol-2-yl)azetidine-1-carboxylate was used in the next step without further purification.

후처리

  1. concentrationconcentrated
  2. customThe product tert-butyl 3-(5-methyl-1H-benzo[d]imidazol-2-yl)azetidine-1-carboxylate was used in the next step without further purification

출처 및 근거

ORD 기록
ord-642238df95114d4fa20e813eb6d9de42
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946230B2

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