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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Pyridine → 2-[5-(3,5-Bistrifluoromethylpyrazol-1-ylmethyl)-2-(3-chloropyridin-2-yl)-2H-pyrazol-3-yl]-6-chloro-8-methylbenzo[d][1,3]oxazin-4-one

HRID 1842538
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HRID 1842538 반응식
CS(Cl)(=O)=O.[F:6][C:7]([F:34])([F:33])[C:8]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[N:10]([CH2:17][C:18]2[CH:19]=[C:20]([C:30](O)=[O:31])[N:21]([C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][N:24]=3)[N:22]=2)[N:9]=1.N1C=CC=CC=1.[NH2:41][C:42]1[C:51]([CH3:52])=[CH:50][C:49]([Cl:53])=[CH:48][C:43]=1[C:44](NC)=[O:45]>C(#N)C>[F:34][C:7]([F:6])([F:33])[C:8]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[N:10]([CH2:17][C:18]2[CH:19]=[C:20]([C:30]3[O:31][C:44](=[O:45])[C:43]4[CH:48]=[C:49]([Cl:53])[CH:50]=[C:51]([CH3:52])[C:42]=4[N:41]=3)[N:21]([C:23]3[C:28]([Cl:29])=[CH:27][CH:26]=[CH:25][N:24]=3)[N:22]=2)[N:9]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 1049Pyridine2회HCID 31297Methanesulfonyl chloride2회HCID 250682512-Amino-5-Chloro-N,3-DimethylbenzamideHCID 866385275-(3,5-bistrifluoromethylpyrazol-1-ylmethyl)-2-(3-chloropyridin-2-yl)-2H-pyrazole-3-carboxylic acid

생성물 1

HCID 591730282-[5-(3,5-Bistrifluoromethylpyrazol-1-ylmethyl)-2-(3-chloropyridin-2-yl)-2H-pyrazol-3-yl]-6-chloro-8-methylbenzo[d][1,3]oxazin-4-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매3회

실험 절차

Under argon 0.12 ml (1.60 mmol) of methanesulphonyl chloride in 3 ml of acetonitrile are cooled to 0° C. and subsequently a solution of 540 mg (1.228 mmol) of 5-(3,5-bistrifluoromethylpyrazol-1-ylmethyl)-2-(3-chloropyridin-2-yl)-2H-pyrazole-3-carboxylic acid in 0.17 ml (2.09 mmol) of pyridine and 6 ml of acetonitrile is added dropwise. The mixture is stirred at this temperature for 15 minutes and then a solution of 228 mg (1.228 mmol) of 2-amino-5-chloro-3,N-dimethylbenzamide in 0.35 ml (4.30 mmol) of pyridine and 6 ml of acetonitrile is added. After a further 15 minutes at 0° C. the mixture is admixed with 0.12 ml (1.60 mmol) of methanesulphonyl chloride and warmed slowly to room temperature overnight. The solvent is removed in vacuo, 15 ml of water are added and the crystals formed are filtered off with suction.

후처리

  1. customThe solvent is removed in vacuo, 15 ml of water
  2. additionare added
  3. customthe crystals formed
  4. filtrationare filtered off with suction

출처 및 근거

ORD 기록
ord-96a6e6f81dc04e14bda22b6891e4cd1d
출처 데이터셋
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08946236B2

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